NEW YORK (Reuters Health) – The experimental weight-loss drug lorcaserin may spur modest weight loss without the heart risks of some older drugs, a new clinical trial confirms — though whether the medication will ever reach the market remains up in the air.
Last October, the U.S. Food and Drug Administration (FDA) declined to approve lorcaserin as an obesity treatment, citing research in rats that suggested there could be a cancer risk.
This latest study, reported in the Journal of Clinical Endocrinology and Metabolism, backs up earlier research showing that lorcaserin can shave off some extra pounds.
Of 4,000 obese adults who used the drug for a year, more than 40 percent lost at least five percent of their initial weight — versus a quarter of those given placebo pills who lost that much.
And the drug facilitated weight loss without raising the risk of heart-valve damage, according to the findings.
Reports of fatal heart-valve problems are what caused the infamous diet drug known as “fen-phen” to be pulled from the market in 1997.
Still, it’s unclear whether lorcaserin will ultimately play any role in the battle against obesity, which now affects about one-third of U.S. adults.
The drug’s maker, Arena Pharmaceuticals Inc, has said it will
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