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Blood Pressure Drug: GI Side Effects?

PHOTO: A handful of patients holding olmesartan reported vomiting, diarrhea and weight loss, according to a Mayo Clinic.

A drug used for treating high blood pressure has been related with a series of serious gastrointestinal side effects, according to a report from a Mayo Clinic.

Between 2008 and 2011, 22 patients holding a drug olmesartan, sole underneath a code name Benicar, suffered symptoms identical to celiac disease, including ongoing diarrhea, vomiting, abdominal inflammation and weight loss. Fourteen of a patients had to be hospitalized.

Doctors attempted putting a patients on a gluten-free diet, a standard resolution for treating celiac disease, though to no avail. When patients stopped holding olmesartan, their symptoms softened dramatically.

Dr. Joseph Murray, a Mayo Clinic gastroenterologist who treated a patients, pronounced a problem is many expected really rare.

“The summary to people holding this drug is that they should not stop their medications,” Murray pronounced in a press conference. “If they’re carrying GI problems, they should speak with their doctors.”


PHOTO: A handful of patients holding olmesartan reported vomiting, diarrhea and weight loss, according to a Mayo Clinic.

PHOTO: A handful of patients holding olmesartan reported vomiting, diarrhea and weight loss, according to a Mayo Clinic.













Olmesartan is an angiotensin II receptor blocker, or ARB, a renouned category of drugs used to provide high blood pressure. According to a U.S. Food and Drug Administration, pharmacies dispensed a drug to 1.2 million Americans in 2010. About 68 million Americans have high blood pressure, according to a U.S. Centers for Disease Control and Prevention.

Doctors are doubtful that a commentary request to many of a people who take olmesartan or other ARBs. Dr. Franz Messerli, executive of a hypertension module during St. Luke’s-Roosevelt Hospital in New York, pronounced only since a side effects stopped when patients stopped holding a drug doesn’t indispensably meant that a drug caused those side effects.

“Only re-exposure [to a drug] can endorse that a GI side effects were indeed due to olmesartan,” he said.

And many doctors contend that GI side effects from a drug are really uncommon.

“I use this representative all a time with glorious formula with honour to blood vigour lowering,” pronounced Dr. Henry Black, clinical highbrow of cardiology during NYU-Langone Medical Center. “I find it really formidable to trust that this really tiny representation of people means anything.”

Black pronounced it’s some-more critical to know either other drugs in a ARB family have constructed identical side effects.

Other doctors pronounced there are other some-more expected explanations for a reported side effects.

“The news from a Mayo Clinic would advise a drug allergy of sorts and commentary that would not describe to a resource of movement of this drug,” pronounced Dr. Domenic Sica, a highbrow of medicine and pharmacology during Virginia Commonwealth University Health System.

Murray pronounced he reported a cases to a FDA, that undertook the possess investigate of patients on ARB drugs who were liberated from hospitals with a diagnosis of celiac disease. The group found no poignant link.

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