Courtesy Skin Physicians & SurgeonsMore

Most dermatologists will tell you never to pop a pimple of any kind on your face, or any other body part for that matter. While famed MD, Sandra Lee—”Dr. Pimple Popper” herself—mostly agrees, she notes that out of all the types of pimples you can have, there’s one that tops the “do not pop” list: cystic acne.

“This is the most severe form of acne, in which the inflammation is situated more deeply under the skin,” she tells Reader’s Digest; it also tends to be the most painful type of acne. And unlike other types of acne—whiteheads and blackheads, for example—you won’t be able to successfully squeeze cystic acne: Pushing on the area will only make the area look and feel

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