FILE PHOTO: A Cannabis plant is pictured at the “Weed the People” event as enthusiasts gather to celebrate the legalization of the recreational use of marijuana in Portland, Oregon July 3, 2015. REUTERS/Steve DipaolaMore

By Lisa Rapaport

(Reuters Health) – People who regularly use cannabis may need more than twice the usual dose of anesthesia for surgery, a U.S. study suggests.

As a growing number of U.S. states legalize marijuana for medical and recreational use, more patients who use the drug are showing up in operating rooms across the country. To get a clearer picture of how cannabis impacts the effectiveness of different types of anesthesia, researchers studied 250 patients who had minimally invasive procedures requiring anesthesia in Colorado, where recreational marijuana use is legal.

Twenty-five patients, or

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