US scientists say they used HIV to make a gene therapy that cured eight infants of severe combined immunodeficiency, or “bubble boy” disease.
Results of the research, developed at a Tennessee hospital, were published in the New England Journal of Medicine.
The babies, born with little to no immune protection, now have fully functional immune systems.
Untreated babies with this disorder have to live in completely sterile conditions and tend to die as infants.
The gene therapy involved collecting the babies’ bone marrow and correcting the genetic defect in their DNA soon after their birth.
The “correct” gene – used to fix the defect – was inserted into an altered version of one of HIV, the virus that causes AIDS.
Researchers said most of the babies were