The first people to be gene-edited – a pair of baby twin girls – may have been mutated in a way that shortens life expectancy, research suggests.

Prof He Jiankui shocked the world when he genetically altered the twins to try to give them protection against HIV.

But a study in Nature Medicine shows people who naturally have the mutation he was trying to recreate were significantly more likely to die young.

Experts said He’s actions were “very dangerous” and “foolish”.

What was Prof He trying to do?

Prof He was targeting a gene called CCR5.

It is a set of genetic instructions that are important for how the immune system functions.

However, they are also the doorway that human immunodeficiency virus (HIV) walks through to infect

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