A new typhoid vaccine works “fantastically well” and is being used to help stop an almost untreatable strain of the infection, doctors say.

Cases of the bacterial disease fell by more than 80% in trials, published in the New England Journal of Medicine.

Experts said the vaccine was a game-changer and would reduce the “terrible toll wrought by typhoid”.

Nine million children are being immunised in Pakistan, where typhoid is now extremely resistant to antibiotics.

What is typhoid fever?

Typhoid fever is caused by highly contagious Salmonella Typhi bacteria and spread through contaminated food and water.

It is a disease of poverty, most common in countries with poor sanitation and a lack of clean water.

Symptoms include:

prolonged fever headache nausea loss of appetite constipation

It causes fatal complications, such as internal

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