Toxic Cell Atlas Guides New Therapies for NeurodegenerationToxic Cell Atlas Guides New Therapies for Neurodegeneration

PR Newswire

SAN FRANCISCO, April 13, 2020

New study generates an “atlas” of toxic immune cells in the brain

SAN FRANCISCO, April 13, 2020 /PRNewswire/ — A common thread in many inflammatory and neurodegenerative diseases, including multiple sclerosis (MS), is damage caused by oxidative stress. Oxidative stress occurs when cells produce toxic substances known as reactive oxygen species, which are damaging nerve cells and other cells in the body.

Gladstone researchers Jae Kyu Ryu, Katerina Akassoglou, and Andrew Mendiola developed a novel method to profile toxic immune cells in the brain, and used it to identify a therapeutic target for multiple sclerosis.

In patients with progressive MS, brain immune cells called microglia are now recognized to