Some time in mid-June, state officials expect to hit a target once thought to be a stretch: fully vaccinating 4.1 million Massachusetts residents — nearly three-quarters of the adult population — against the relentless coronavirus.

That milestone will permit a return to normal life for most people, health experts say, citing recent sharp declines in COVID-19 cases, hospitalizations, and deaths. But it likely won’t be enough to stamp out the virus or prevent future spikes in vulnerable pockets of the population, they caution.

“This virus has humbled us so many times over the last 16 months,” said Dr. Howard Koh, professor at Harvard’s T. H. Chan School of Public Health and a former Massachusetts public health commissioner. “Very few scientists are ready to say we’re going to

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