Covid-19 rebound is probably more common than data suggests, but Paxlovid is still effective – CNN

by | Aug 26, 2022 | COVID-19

However, some people who take Paxlovid — and some who don’t — experience a rebound case of Covid-19, with a resurgence of symptoms or positive tests just days after completing treatment and testing negative. And recent high-profile rebound cases, including President Joe Biden, Dr. Anthony Fauci and first lady Jill Biden, are raising questions about just how frequently this happens. “From the data we have so far, Covid-19 rebound is a relatively infrequent event — this is not happening the majority of the time,” a spokesperson from the US Centers for Disease Control and Prevention told CNN. “A small percentage of people with Covid-19 experience a rebound of symptoms, including those who take antiviral medication, such as Paxlovid.”Experts say that rebound cases are probably more common than data suggests, but it’s difficult to know by exactly how much. There’s a wide range of estimates for what that “small percentage” might be — from less than 1% of people who take Paxlovid to more than 10% — and definitions of a rebound case are lacking consistency. And a “brief return of symptoms may be part of the natural history of SARS-CoV-2 (the virus that causes COVID-19) infection in some persons, independent of treatment with Paxlovid and regardless of vaccination status,” according to a health advisory issued by the CDC.It’s important to get a better handle on the specifics for both individual patients and the broader community, says Dr. Michael Charness, of the Veterans Administration Medical Center in Boston, who has collaborated with a team of researchers at Columbia University to look into cases of Covid-19 that return after Paxlovid treatment. People experiencing a rebound case can be contagious, so they should be aware of the possibility that they might need to reisolate in line with CDC guidance, he said. And for others, the return of symptoms or a positive test can “certainly be a source of concern for many people, wondering ‘Why is this happening to me?'”Tracking Covid-19 reboundIn clinical trial documents submitted to the US Food and Drug Administrati …

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