COVID-19 Rebound Not Caused by Paxlovid-Induced Weak Immune Response – Contagionlive.com

by | Oct 11, 2022 | COVID-19

Overcoming COVID-19 infection is an accomplishment to be celebrated, but this is dampened by a recurrence of clinical symptoms.Rebound COVID-19 infection after treatment with nirmatrelvir–ritonavir (Paxlovid) has amassed international attention, especially because there is no clear cause. One study, published this week in Clinical Infectious Diseases, analyzed what causes certain people to have a rebound COVID-19 infection.The investigation was led by the National Institute of Allergy and Infectious Diseases (NIAID) and sought to identify the clinical course of COVID-19 rebound, as well as the immunologic and virologic characteristics of these rebound patients after Paxlovid therapy.The Centers for Disease Control and Prevention (CDC) defines COVID-19 rebound as a resurgence of COVID-19 symptoms and/or a new positive diagnostic test after having tested negative.The adult study patients were chosen from participants enrolled in an ongoing National Institutes of Health (NIH) study in Bethesda, Maryland. The 8 qualifying participants provided blood samples and access to their COVID-19 medical records.The participants included 6 people who took Paxlovid within 4 days of COVID-19 symptom onset and later experienced rebound infection. Among this cohort, there were 3 men and 3 women, with an average age of 42 years. There were 2 participants, a 54-year-old man and 35-year-old woman, who did not take Paxlovid but still experienced COVID-19 rebound.A control group of 6 people who contracted COVID-19 but had no rebound infection was also included in the study. All study patients had been fully vaccinated and boosted against COVID-19, and none developed severe disease necessitating hospitalization.Nasal swabs positive for COVID-19 were used for v …

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