COVID-19 Scan for Oct 24, 2022 – CIDRAP

by | Oct 24, 2022 | COVID-19

Symptoms after COVID vaccination tied to greater antibody responseA study published late last week in JAMA Network Open links systemic symptoms—those that affect the entire body—after receipt of two doses of mRNA COVID-19 vaccine with stronger SARS-CoV-2 antibody responses than in vaccinees with no or localized symptoms.In February 2021, a team led by Columbia University researchers invited US adult participants in the Framingham Heart Study, which has been ongoing since 1948, to answer questions on COVID-19 vaccination and symptoms and to submit a dried-blood spot to test their antibody responses to two doses of the Pfizer/BioNTech or Moderna vaccine received at least 2 weeks earlier.Vaccine-related symptoms were characterized as either systemic (fever, chills, muscle pain, nausea, vomiting, headache, and moderate or severe fatigue) or local (pain at the injection site or rash). Average age of the 928 respondents was 65 years, 39% were men, 96% were White, and 9% reported a previous COVID-19 infection.After each dose, 48% of participants reported systemic symptoms, while 12% reported only local symptoms, and 40% were asymptomatic. A bivariate analysis tied the presence of symptoms to younger age, female sex, previous infection, and the Moderna vaccine.Antibody reactivity was detected in 98% of asymptomatic participants, 99% with local-only symptoms, and 99% with systemic s …

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