Treated or Not, COVID-19 Recurrence Seems Symptomatic for Some – UC San Diego Health

by | Oct 31, 2022 | COVID-19

Researchers at University of California San Diego School of Medicine, with colleagues from the
ACTIV-2 trial, part of the U.S. government’s response to COVID-19, investigated whether symptoms of COVID-19 recurred following a two-day symptom-free period in persons who did not receive any treatment for the disease. They sought to determine whether such recurrences might be different from those that have been documented in persons treated with Paxlovid, a phenomenon known as Paxlovid rebound.Writing in the Oct 27, 2022 issue of
JAMA Network Open, the scientists tracked 13 defined COVID-19 symptoms for 29 days in 158 untreated study participants. They found that more than one-third of the participants who reported complete resolution of symptoms for at least two consecutive days subsequently reported a return of symptoms.
Davey Smith MD, is head of Infectious Diseases and Global Public Health at UC San Diego School of Medicine and an infectious disease specialist at UC San Diego Health.”It is clear that COVID-19 has waxing and waning of symptoms, whether they are treated or not,” said the study’s lead author
Davey M. Smith, MD, head of Infectious Diseases and Global Public Health at UC San Diego School of Medicine and an infectious disease specialist at UC San Diego Health.In late-2021, the U.S. Food and Drug Administration issued an emergency use authorization for Paxlovid, a combination of two oral antiviral drugs (nirmatrelvir and ritonavir) that has since become the primary frontline treatment for COVID-19. Clinical trial data suggests Paxlovid significantly reduces the risk of severe illness, hospitalization and death.But treatment efficacy has proven ephe …

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